Mass treatment/prophylaxis during an outbreak of infectious syphilis in Vancouver, British Columbia.

نویسندگان

  • M Rekart
  • D Patrick
  • A Jolly
  • T Wong
  • M Morshed
  • H Jones
  • C Montgomery
  • L Knowles
  • N Chakraborty
  • J Maginley
چکیده

Syphilis is a sexually transmitted disease (STD) caused by the spirochete Treponema pallidum which is restricted to humans. Transmission occurs primarily during the infectious phase which consists of primary, secondary, and early latent syphilis. Primary syphilis is characterized by a painless ulcer approximately 3 weeks after exposure. Secondary syphilis is characterized by a generalized eruption 4 to 6 weeks after the primary stage in untreated patients. After weeks or several months, secondary manifestations resolve and about one-third of untreated cases become clinically latent sometimes leading to late manifestations involving the cardiovascular system, the central nervous system, skin, bones, and viscera. A diagnosis of early latent syphilis is made when the clinical situation and nontreponemal antibody titres reflect recent infection for which aggressive follow-up is necessary. Perinatal transmission can occur, especially during the infectious phase. The diagnosis of syphilis relies on clinical examination, darkfield demonstration of spirochetes in lesion exudate, nonspecific treponemal antibody tests (rapid plasma reagin test and Venereal Disease Research Laboratory test), and specific treponemal antibody tests (microhemagglutination for Treponema pallidum and fluorescent treponemal antibody absorption test). The current treatment of choice is intramuscular benzathine penicillin G.

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عنوان ژورنال:
  • Canada communicable disease report = Releve des maladies transmissibles au Canada

دوره 26 12  شماره 

صفحات  -

تاریخ انتشار 2000